Análise das potenciais interações medicamentosas e eventos adversos

Autores

DOI:

10.24281/rremecs2024.9.15.6881

Palavras-chave:

Envelhecimento, Interações Medicamentosas, Saúde do Idoso

Resumo

Analisar as potenciais interações medicamentosas e os eventos adversos. Estudo transversal e quantitativo, realizado em um ambulatório na cidade de São Paulo - SP, com 117 idosos, no período de março a novembro de 2019. A coleta de dados foi realizada pela transcrição integral dos receituários, as interações medicamentos foram analisadas na base de dados Drugs.com. e, após, realizada análise por estatística descritiva. Na categoria grave, 40% foram entre o anlodipino versus a sinvastatina, as moderadas, entre a hidroclorotiazida versus a metformina (5,8%) e as leves entre a hidroclorotiazida versus o anlodipino (17,9%). As interações entre os medicamentos versus alimentos foram na categoria grave entre a sinvastatina e os derivados da frutose (87,5%), na moderada entre a losartana e o sal (20,8%) e as leves entre o anlodipino e os derivados da frutose (85,1%). Portanto, ressalta-se a importância das orientações de enfermagem planejamento assistencial da terapia medicamentosa.

Descritores: Envelhecimento, Interações Medicamentosas, Saúde do Idoso.

 

Analysis of potential drug interactions and adverse events

Abstract: To analyze drug interactions and adverse events. Cross-sectional and quantitative study, carried out in an outpatient clinic in the city of São Paulo - SP, with 117 elderly people, from March to November 2019. Data collection was carried out by full transcription of the prescriptions, drug interactions were evidenced in the Drugs.com database. and, after, analysis carried out using descriptive statistics. In the severe category, 40% were between amlodipine versus simvastatin, moderate levels between hydrochlorothiazide versus metformin (5.8%) and levels between hydrochlorothiazide versus amlodipine (17.9%). Interactions between medicines and foods were in the severe category between simvastatin and fructose derivatives (87.5%), in the moderate category between losartan and salt (20.8%) and between amlodipine and fructose derivatives. fructose (85.1%). Therefore, the importance of nursing guidelines for care planning for drug therapy is highlighted.

Descriptors: Aging, Drug Interactions, Health of the Elderly.

 

Análisis de posibles interacciones medicamentosas y eventos adversos

Resumen: Analizar interacciones medicamentosas y eventos adversos. Estudio transversal y cuantitativo, realizado en un ambulatorio de la ciudad de São Paulo - SP, con 117 ancianos, de marzo a noviembre de 2019. La recolección de datos se realizó mediante transcripción completa de las prescripciones, se determinaron las interacciones entre medicamentos. evidenciado en la base de datos de Drugs.com. y, posteriormente, análisis realizado mediante estadística descriptiva. En la categoría grave, el 40% estuvo entre amlodipino versus simvastatina, los niveles moderados entre hidroclorotiazida versus metformina (5,8%) y los niveles entre hidroclorotiazida versus amlodipino (17,9%). Las interacciones entre medicamentos y alimentos se ubicaron en la categoría grave entre simvastatina y derivados de fructosa (87,5%), en la categoría moderada entre losartán y sal (20,8%) y entre amlodipino y fructosa (85,1%). Por lo tanto, se destaca la importancia de las directrices de enfermería para la planificación del cuidado de la terapia farmacológica.

Descriptores: Envejecimiento, Interacciones Farmacológicas, Salud del Anciano.

Referências

Rankin A, Cadogan CA, Patterson SM, Kerse N, Cardwell CR, Bradley MC, et al. Interventions to improve the appropriate use of polypharmacy for older people. Cochrane Database Syst Rev. 2018; 9:CD008165.

Redmond P, Grimes TC, McDonnell R, Boland F, Hughes C, Fahey T. Impact of medication reconciliation for improving transitions of care. Cochrane Database Syst Rev. 2018; 8:CD010791.

Haerig TR, Krause D, Klaassen-Mielke R, Rudolf H, Trampisch HJ, Thuermann P. Potentially inappropriate medication including drug-drug interaction and the risk of frequent falling, hospital admission, and death in older adults - results of a large cohort study (getABI). Front Pharmacol. 2023; 14:1062290.

Santos TO, Nascimento MM, Nascimento YA, Oliveira GC, Martins UC, Silva DF, et al. Drug interactions among older adults followed up in a comprehensive medication management service at Primary Care. Einstein (São Paulo). 2019; 17(4):eAO4725.

Veloso RCSG, Figueredo TP, Barroso SCC, Nascimento MMG, Reis AMM. Factors associated with drug interactions in elderly hospitalized in high complexity hospital. Cien Saúde Colet. 2019; 24(1):17-26.

Dias BM, Santos FS, Reis AMM. Potential drug interactions in drug therapy prescribed for older adults at hospital discharge: cross-sectional study. Sao Paulo Med J. 2019; 137(4):369-78.

Drug Interactions Checker. Drug Information Online. Disponível em: <http://www.drugs.com/drug_interactions.html>. Acesso em 10 jun 2020.

Kozioleka M, Alcarob S, Augustijnsd P, Basite AW, Grimma M, Hensd B, et al. The mechanisms of pharmacokinetic food-drug interactions - a perspective from the UNGAP group. Eur J Pharm Sci. 2019; 134:31–59.

Von Elm E, Altman DG, Egger M, Pocock SJ, Gotzsche PC, Vandenbroucke JP; STROBE Initiative. The Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) statement: guidelines for reporting observational studies. J Clin Epidemiol. 2008; 61(4):344-9.

Maia APA, Freitas LT. Arterial hypertension and possible drug interactions: A careful look of the pharmacist in caring for the elder. Brazilian Journal of Development. 2021; 7(5):48245-55.

Andrade KVF, Souza AM. Prevalence of potential drug-drug interactions in hypertensive individuals followed in Family Health Strategy, Brazil. J Health Biol Sci. 2018; 6(4):405-411.

Morais KB, Dantas LA, Triches CMF, Porfiro CA, Filho MAN, Santos JSG. Drug interactions with antihypertensives. Research, Society and Development. 2022; 11(2):e4411225488.

Santos JND, Veloso RCSG, Tinoco MS, Reis AMM. Fatores associados a interações medicamentosas de relevância clínica com estatinas em pacientes ambulatoriais com doença arterial coronariana. Mundo da Saúde. 2020; 44:506-514, e0202020.

Cahir C, Wallace E, Cummins A, Teljeur C, Byrne C, Bennett K, et al. Identifying Adverse Drug Events in Older Community-Dwelling Patients. Ann Fam Med. 2019; 17(2):133-140.

Oliveira LM, Diel JAC, Nunes A, Pizzol TAD. Prevalence of drug interactions in hospitalised elderly patients: a systematic review. Eur J Hosp. Pharm.2021; 28:4-9.

Arantes AC, Sousa ALL, Vitorino PVO, Jardim PCBV, Jardim TSV, Rezende JM. Effects of added salt reduction on central and peripheral blood pressure. Arq Bras Cardiol. 2020; 114(3):554-561.

Costa FA, Moura KVN, Veloso F, Póvoa R. Nonpharmacologic treatment of arterial Hypertension. Rev Bras Hipertens. 2019; 26(1):13-6.

Tiguman GMB, Biase TMMA, Silva MT, Galvão TF. Prevalence and factors associated with polypharmacy and potential drug interactions in adults in Manaus, Amazonas state, Brazil: a cross-sectional population-based study, 2019. Epidemiol Serv Saúde. 2022; 31(2):e2021653.

Holton A, Boland F, Gallagher P, Fahey T, Moriarty F, Kenny RA, et al. Potentially serious alcohol–medication interactions and falls in community-dwelling older adults: a prospective cohort study. Age and Ageing. 2019; 48:824-831.

Sousa CR, Coutinho JFV, Freire Neto JB, Barbosa RGB, Marques MB, Diniz JL. Factors associated with vulnerability and fragility in the elderly: a cross-sectional study. Rev Bras Enferm. 2022; 75(2):e20200399.

Tomazela M, Valente SH, Lima MA, Bulgarelli AF, Fabriz LA, Zacharias FC, et al. Care transition of older adults from hospital to home. Acta Paul Enferm. 2023; 36:eAPE00291.

Insani WN, Whittlesea C, Alwafi H, Man KKC, Chapman S, Wei L. Prevalence of adverse drug reactions in the primary care setting: a systematic review and meta-analysis. PLoS ONE. 2021; 16(5):e0252161.

Khalil H, Huang C. Adverse drug reactions in primary care: a scoping review. BMC Health Serv Res. 2020; 20:5.

Santos CO, Lazaretto FZ, Lima LH, Azambuja MS, Millão LF. Medication reconciliation: implantation process in a hospital complex with the use of electronic system. Saúde Debate. 2019; 43(121):368-77.

Macêdo GGC, Oliveira-Figueirêdo DST, Andrade LL, Carvalho MAP. Factors related to the knowledge of nursing professionals about pharmacovigilance. Rev Rene. 2020; 21:e44118.

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23-02-2024
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SOARES, C. R. .; OKUNO, M. F. P. . Análise das potenciais interações medicamentosas e eventos adversos. Revista Remecs - Revista Multidisciplinar de Estudos Cientí­ficos em Saúde, [S. l.], v. 9, n. 15, p. 68–81, 2024. DOI: 10.24281/rremecs2024.9.15.6881. Disponível em: https://www.revistaremecs.com.br/index.php/remecs/article/view/1537. Acesso em: 11 dez. 2024.